Norfluoxetine

Chemical Properties

SMILES NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight 295.1

Drug Properties

Type Small molecule
Endogenous No
Approved No
InChIKey WIQRCHMSJFFONW-UHFFFAOYSA-N

Database Connections

External Links


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.5 6.5 6.5 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.54 5.95 6.51 PDSP KiDatabase
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.38 5.93 PDSP KiDatabase
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.53 5.53 5.53 PDSP KiDatabase
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 4.0 4.15 4.3 PDSP KiDatabase
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.04 6.04 6.04 PDSP KiDatabase
H1 HRH1 Human Histamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
D2 DRD2 Human Dopamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 4.92 4.92 4.92 PDSP KiDatabase
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 4.34 4.34 4.34 PDSP KiDatabase
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.12 5.12 5.12 PDSP KiDatabase
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 4.59 4.59 4.59 PDSP KiDatabase
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 4.66 4.66 4.66 PDSP KiDatabase