GPCRdb

naphazoline

Agent/drug
Bioactivity

naphazoline

SMILES	c1ccc2c(CC3=NCCN3)cccc2c1
InChIKey	CNIIGCLFLJGOGP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	210.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.50	6.50	6.50	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.00	7.00	7.00	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.68	7.68	7.68	PDSP Ki database
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	7.77	7.86	7.94	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.39	6.39	6.39	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.64	8.64	8.64	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.39	6.39	6.39	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 11 of 11 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	6.60	7.75	8.90	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	7.20	7.20	7.20	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.80	7.80	7.80	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.10	7.10	7.10	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	7.69	7.69	7.69	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	7.26	7.26	7.26	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	6.85	6.85	6.85	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pIC50	5.94	5.94	5.94	ChEMBL

Showing 1 to 8 of 8 entries

naphazoline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 6

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	S01G, R01A	0.606	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic rhinosinusitis, unspecified	CA0A.Z	S01G, R01A	0.599	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified diseases of the visual system	9E1Y	S01G, R01A	0.037	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	S01G, R01A	0.606	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic rhinosinusitis, unspecified	CA0A.Z	S01G, R01A	0.599	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified diseases of the visual system	9E1Y	S01G, R01A	0.037	1	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	S01G, R01A	0.606	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic rhinosinusitis, unspecified	CA0A.Z	S01G, R01A	0.599	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified diseases of the visual system	9E1Y	S01G, R01A	0.037	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.596	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.551	4	Yes

Showing 1 to 20 of 36 entries

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naphazoline

naphazoline

Chemical Properties

Database connections

Bioactivities

naphazoline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information