cyproheptadine
SMILES | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 |
InChIKey | JJCFRYNCJDLXIK-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 1 |
Hydrogen bond donors | 0 |
Rotatable bonds | 0 |
Molecular weight (Da) | 287.2 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.8 | 6.8 | 6.8 | Guide to Pharmacology |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.1 | 7.3 | 7.5 | Guide to Pharmacology |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
H1 | HRH1 | Human | Histamine | A | pKi | 10.2 | 10.2 | 10.2 | Guide to Pharmacology |
D2 | DRD2 | Mouse | Dopamine | A | pKi | 6.95 | 6.95 | 6.95 | ChEMBL |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.3 | 7.3 | 7.3 | ChEMBL |
H1 | HRH1 | Guinea pig | Histamine | A | pKd | 9.0 | 9.0 | 9.0 | ChEMBL |
H1 | HRH1 | Guinea pig | Histamine | A | pKi | 9.27 | 9.27 | 9.27 | ChEMBL |
5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.9 | 5.9 | 5.9 | ChEMBL |
α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 7.36 | 7.36 | 7.36 | ChEMBL |
α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.01 | 7.01 | 7.01 | ChEMBL |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.28 | 7.28 | 7.28 | ChEMBL |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.77 | 7.77 | 7.77 | ChEMBL |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.56 | 8.56 | 8.56 | ChEMBL |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.73 | 6.73 | 6.73 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 6.71 | 6.71 | 6.71 | ChEMBL |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.9 | 7.1 | 7.3 | ChEMBL |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.66 | 8.66 | 8.66 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pKd | 5.27 | 5.27 | 5.27 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pKi | 9.37 | 9.37 | 9.37 | ChEMBL |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.02 | 8.02 | 8.02 | ChEMBL |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 7.16 | 7.16 | 7.16 | ChEMBL |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.97 | 6.97 | 6.97 | ChEMBL |
D1 | DRD1 | Human | Dopamine | A | pKi | 7.1 | 7.1 | 7.1 | ChEMBL |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.89 | 6.89 | 6.89 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.22 | 8.22 | 8.22 | ChEMBL |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.92 | 7.92 | 7.92 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.96 | 8.43 | 8.89 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.8 | 7.8 | 7.8 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.52 | 9.05 | 9.56 | ChEMBL |
5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 7.86 | 7.95 | 8.08 | PDSP Ki database |
5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.32 | 5.57 | 6.08 | PDSP Ki database |
D2 | DRD2 | Human | Dopamine | A | pKi | 6.95 | 7.11 | 7.26 | ChEMBL |
5-HT1A | A0A4X1UTF5 | Pig | 5-Hydroxytryptamine | A | pKi | 6.45 | 6.45 | 6.45 | PDSP Ki database |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 5.89 | 6.03 | 6.17 | PDSP Ki database |
5-HT1D | F1MMU1 | Bovine | 5-Hydroxytryptamine | A | pKi | 5.92 | 5.92 | 5.92 | PDSP Ki database |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 7.81 | 8.72 | 9.36 | PDSP Ki database |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.59 | 8.49 | 9.34 | PDSP Ki database |
5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pKi | 8.52 | 8.52 | 8.52 | PDSP Ki database |
D1 | DRD1 | Human | Dopamine | A | pKi | 6.93 | 7.46 | 8.0 | PDSP Ki database |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.21 | 7.3 | PDSP Ki database |
D3 | DRD3 | Human | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | PDSP Ki database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.55 | 7.84 | 8.2 | PDSP Ki database |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.87 | 6.87 | 6.87 | PDSP Ki database |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.11 | 7.3 | 7.47 | PDSP Ki database |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.82 | 6.9 | 7.02 | PDSP Ki database |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.59 | 8.7 | 8.81 | PDSP Ki database |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.74 | 8.2 | 8.65 | PDSP Ki database |
5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 6.3 | 6.6 | 6.9 | PDSP Ki database |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.91 | 7.11 | 7.52 | PDSP Ki database |
H1 | HRH1 | Human | Histamine | A | pKi | 10.22 | 10.22 | 10.22 | PDSP Ki database |
H1 | HRH1 | Guinea pig | Histamine | A | pKi | 10.0 | 10.0 | 10.0 | PDSP Ki database |
H3 | HRH3 | Human | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
H4 | HRH4 | Human | Histamine | A | pKi | 5.0 | 5.85 | 6.7 | PDSP Ki database |
5-HT2B | 5HT2B | Mouse | 5-Hydroxytryptamine | A | pKi | 7.65 | 7.65 | 7.65 | PDSP Ki database |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.28 | 6.26 | 6.96 | PDSP Ki database |
D2 | DRD2 | Bovine | Dopamine | A | pKi | 7.19 | 7.19 | 7.19 | PDSP Ki database |
D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.92 | 5.92 | 5.92 | PDSP Ki database |
D2 | DRD2 | Rat | Dopamine | A | pKi | 6.95 | 6.95 | 6.95 | PDSP Ki database |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.72 | 7.82 | 7.92 | PDSP Ki database |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.74 | 7.95 | 8.15 | PDSP Ki database |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.72 | 7.91 | 8.1 | PDSP Ki database |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.93 | 8.14 | 8.35 | PDSP Ki database |
5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 5.8 | 5.8 | 5.8 | PDSP Ki database |
5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 7.24 | 7.24 | 7.24 | PDSP Ki database |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.92 | 7.92 | 7.92 | PDSP Ki database |
D4 | DRD4 | Human | Dopamine | A | pKi | 6.92 | 6.92 | 6.92 | PDSP Ki database |
D5 | DRD5 | Human | Dopamine | A | pKi | 7.22 | 7.22 | 7.22 | PDSP Ki database |
H1 | HRH1 | Guinea pig | Histamine | A | pKd | 8.05 | 8.05 | 8.05 | Drug Central |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
D1 | DRD1 | Human | Dopamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
D2 | DRD2 | Human | Dopamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
D3 | DRD3 | Human | Dopamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
H1 | HRH1 | Human | Histamine | A | pKi | 7.99 | 7.99 | 7.99 | Drug Central |
H4 | HRH4 | Human | Histamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
D2 | DRD2 | Mouse | Dopamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
5-HT2C | 5HT2C | Mouse | 5-Hydroxytryptamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 7.6 | 7.6 | 7.6 | Guide to Pharmacology |
D2 | DRD2 | Human | Dopamine | A | pKi | 6.95 | 7.04 | 7.13 | PDSP Ki database |
H2 | HRH2 | Human | Histamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
H1 | HRH1 | Rat | Histamine | A | pKi | 8.51 | 8.51 | 8.51 | PDSP Ki database |
5-HT2C | 5HT2C | Mouse | 5-Hydroxytryptamine | A | pKi | 7.96 | 7.96 | 7.96 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.56 | 5.56 | 5.56 | ChEMBL |
α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 7.1 | 7.1 | 7.1 | ChEMBL |
α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 6.62 | 6.62 | 6.62 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 7.5 | 7.58 | 7.65 | ChEMBL |
α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 6.97 | 6.97 | 6.97 | ChEMBL |
α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.42 | 7.42 | 7.42 | ChEMBL |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.42 | 8.42 | 8.42 | ChEMBL |
α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 5.89 | 5.89 | 5.89 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pIC50 | 6.7 | 6.7 | 6.7 | ChEMBL |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pIC50 | 8.43 | 8.43 | 8.43 | ChEMBL |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.34 | 7.34 | 7.34 | ChEMBL |
D2 | DRD2 | Rat | Dopamine | A | pIC50 | 6.85 | 6.85 | 6.85 | ChEMBL |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 6.91 | 6.91 | 6.91 | ChEMBL |
α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.55 | 6.55 | 6.55 | ChEMBL |
D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.8 | 6.8 | 6.8 | ChEMBL |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 6.55 | 6.55 | 6.55 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 8.03 | 8.03 | 8.03 | ChEMBL |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.46 | 7.46 | 7.46 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 8.61 | 8.61 | 8.61 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pIC50 | 7.32 | 7.32 | 7.32 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 9.01 | 9.01 | 9.01 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pIC50 | 6.79 | 6.79 | 6.79 | ChEMBL |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.0 | 5.33 | 6.0 | ChEMBL |
α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.18 | 8.18 | 8.18 | Drug Central |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.16 | 8.16 | 8.16 | Drug Central |
D2 | DRD2 | Rat | Dopamine | A | pIC50 | 8.16 | 8.16 | 8.16 | Drug Central |