4-hydroxytamoxifen


SMILES CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccc(cc1)O
InChIKey DODQJNMQWMSYGS-QPLCGJKRSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 387.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.22 7.54 7.96 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.09 6.28 6.49 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.71 5.77 5.81 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.47 5.57 5.64 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.59 5.88 6.33 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.38 6.44 6.56 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.31 5.42 5.49 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.0 6.04 6.81 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.0 5.31 5.52 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.63 5.78 5.96 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 5.0 5.11 5.22 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 5.61 5.75 5.86 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.02 6.08 6.19 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
H2 HRH2 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
CB1 CNR1 Rat Cannabinoid A pKi 5.0 5.0 5.0 PDSP Ki database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.0 5.24 5.47 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.21 5.42 5.74 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database