GPCRdb

nortriptyline

Agent/drug
Bioactivity

nortriptyline

SMILES	CNCCC=C1c2ccccc2CCc2ccccc21
InChIKey	PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	263.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.91	6.91	6.91	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.94	6.94	6.94	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.87	6.87	6.87	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.56	6.56	6.56	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.37	7.37	7.37	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.52	7.52	7.52	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.97	5.97	5.97	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.53	6.53	6.53	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.84	5.84	5.84	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.82	7.82	7.82	ChEMBL

Showing 1 to 20 of 57 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.52	8.46	10.40	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.98	7.98	7.98	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.68	6.68	6.68	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.56	6.56	6.56	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.13	6.13	6.13	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.03	7.03	7.03	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.69	6.69	6.69	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.73	5.73	5.73	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.50	5.50	5.50	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.29	7.29	7.29	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.87	6.87	6.87	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.80	7.80	7.80	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	6.26	6.26	6.26	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.27	6.27	6.27	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.75	6.75	6.75	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	10.30	10.30	10.30	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.30	7.30	7.30	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	7.99	7.99	7.99	Drug Central
H₂	HRH2	Human	Histamine	A	pIC50	5.63	5.63	5.63	ChEMBL

Showing 1 to 20 of 28 entries

nortriptyline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 3

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastroparesis	DA41.00	N06A	0.370	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z	N06A	0.089	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified malignant neoplasms of unspecified primary sites	2D4Y	N06A	0.003	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	N06A	0.545	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.632	2	Yes

Showing 1 to 6 of 6 entries