25-hydroxycholesterol
SMILES | O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C |
InChIKey | INBGSXNNRGWLJU-ZHHJOTBYSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 2 |
Rotatable bonds | 5 |
Molecular weight (Da) | 402.4 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Endogenous |
Approved drug | Yes |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pIC50 | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
CRF1 | CRFR1 | Rat | Corticotropin-releasing factor | B1 | pIC50 | 8.15 | 8.15 | 8.15 | ChEMBL |
CRF1 | CRFR1 | Rat | Corticotropin-releasing factor | B1 | pEC50 | 7.4 | 7.4 | 7.4 | ChEMBL |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pEC50 | 7.4 | 7.4 | 7.4 | ChEMBL |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pIC50 | 8.4 | 8.4 | 8.4 | ChEMBL |