oxytocin
| SMILES | None |
| InChIKey | XNOPRXBHLZRZKH-DSZYJQQASA-N |
| Sequence | CYIQNCPLG |
Chemical properties
| Hydrogen bond acceptors | None |
| Hydrogen bond donors | None |
| Rotatable bonds | None |
| Molecular weight (Da) |
Drug properties
| Molecular type | Peptide |
| Endogenous/Surrogate | Endogenous |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 6.9 | 7.6 | 8.3 | Guide to Pharmacology |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKd | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 5.7 | 6.35 | 7.0 | Guide to Pharmacology |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKd | 5.8 | 5.8 | 5.8 | Guide to Pharmacology |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 5.4 | 6.1 | 6.8 | Guide to Pharmacology |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKd | 5.8 | 5.8 | 5.8 | Guide to Pharmacology |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 6.1 | 6.1 | 6.1 | Guide to Pharmacology |
| OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKd | 8.2 | 8.85 | 9.5 | Guide to Pharmacology |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 8.2 | 8.9 | 9.6 | Guide to Pharmacology |
| OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 8.77 | 8.91 | 9.05 | ChEMBL |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 5.75 | 5.75 | 5.75 | ChEMBL |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 5.46 | 5.63 | 5.81 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKd | 8.17 | 8.17 | 8.17 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 8.02 | 8.85 | 9.36 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 6.92 | 7.25 | 7.7 | ChEMBL |
| V1B | V1BR | Rat | Vasopressin and oxytocin | A | pKi | 7.4 | 7.4 | 7.4 | PDSP Ki database |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 7.23 | 7.29 | 7.34 | PDSP Ki database |
| V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 6.0 | 6.08 | 6.17 | PDSP Ki database |
| OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 8.72 | 8.89 | 9.05 | PDSP Ki database |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 6.91 | 6.91 | 6.91 | PDSP Ki database |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 5.75 | 5.75 | 5.75 | PDSP Ki database |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 5.81 | 5.81 | 5.81 | PDSP Ki database |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 9.15 | 9.23 | 9.3 | PDSP Ki database |
| V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 7.06 | 7.13 | 7.21 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| OT | OXYR | Mouse | Vasopressin and oxytocin | A | pEC50 | 8.7 | 8.7 | 8.7 | ChEMBL |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pEC50 | 6.62 | 8.0 | 9.7 | ChEMBL |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pEC50 | 6.09 | 7.11 | 8.14 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pIC50 | 8.57 | 8.57 | 8.57 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pEC50 | 7.58 | 8.85 | 11.0 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pEC50 | 6.58 | 8.28 | 9.74 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pEC50 | 8.16 | 8.16 | 8.16 | Drug Central |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pEC50 | 8.2 | 8.2 | 8.2 | Drug Central |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pEC50 | 8.21 | 8.21 | 8.21 | Drug Central |