(-)-Pindolol

Chemical Properties

SMILES O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight 248.2

Drug Properties

Type Small molecule
Endogenous No
Approved No
InChIKey JZQKKSLKJUAGIC-NSHDSACASA-N

Database Connections

External Links


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Guide to Pharmacology
β1 ADRB1 Human Adrenoceptors A pIC50 9.12 9.12 9.12 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 9.36 9.36 9.36 ChEMBL
β3 ADRB3 Human Adrenoceptors A pIC50 7.32 7.32 7.32 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 7.44 7.44 7.44 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 8.8 8.8 8.8 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 8.97 8.97 8.97 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.55 7.55 7.55 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.88 6.88 6.88 PDSP KiDatabase
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 6.66 6.71 6.77 PDSP KiDatabase
5-HT2C A0A4X1VZZ6 Pig 5-Hydroxytryptamine A pKi 4.0 4.01 4.08 PDSP KiDatabase
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.11 6.38 6.62 PDSP KiDatabase
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 4.15 4.21 4.23 PDSP KiDatabase
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 4.0 4.05 4.11 PDSP KiDatabase
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT1B 5HT1B Guinea pig 5-Hydroxytryptamine A pKi 4.83 4.83 4.83 PDSP KiDatabase