prazosin


SMILES COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
InChIKey IENZQIKPVFGBNW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 9.0 9.45 9.9 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 9.6 9.75 9.9 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 9.5 9.85 10.2 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 5.3 5.9 6.5 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 6.4 6.95 7.5 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 6.7 7.35 8.0 Guide to Pharmacology
α1A ADA1A Rat Adrenoceptors A pKi 9.5 9.5 9.5 Guide to Pharmacology
α2A ADA2A Pig Adrenoceptors A pKi 5.39 5.39 5.39 ChEMBL
α2A ADA2A Bovine Adrenoceptors A pKi 6.97 6.97 6.97 ChEMBL
α2A ADA2A Rat Adrenoceptors A pKi 5.78 5.78 5.78 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 9.03 9.46 9.9 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKd 8.7 9.06 9.77 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 8.86 9.29 9.7 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 8.53 9.59 10.0 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 8.99 9.0 9.01 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 9.48 9.48 9.48 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.1 9.33 9.68 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.44 7.07 7.89 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.98 9.56 10.15 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 8.6 9.0 9.81 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.02 7.22 7.62 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.73 9.4 10.4 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.67 6.12 6.68 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 9.34 9.55 9.77 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.58 5.58 5.58 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.08 5.08 5.08 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.63 5.63 5.63 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.61 6.31 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.1 5.82 6.54 PDSP Ki database
5-HT1D A0A4W2F4L6 Hybrid cattle 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2C ADA2C North American opossum Adrenoceptors A pKi 7.44 7.44 7.44 PDSP Ki database
α2A ADA2A Bovine Adrenoceptors A pKi 6.5 6.5 6.5 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.65 5.98 6.52 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.94 7.4 7.84 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.24 7.64 7.97 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 7.94 8.11 8.27 PDSP Ki database
α1B ADA1B Mouse Adrenoceptors A pKi 9.6 9.72 9.85 PDSP Ki database
α1D ADA1D Rat Adrenoceptors A pKi 9.48 9.48 9.48 PDSP Ki database
α1B ADA1B Rat Adrenoceptors A pKi 9.25 9.25 9.25 PDSP Ki database
MT1 MTR1A Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
MT2 MTR1B Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 9.21 9.71 10.22 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 9.16 9.75 10.22 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 5.94 5.94 5.94 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.01 5.06 PDSP Ki database
α1A F6PTQ1 Pig Adrenoceptors A pKi 9.2 9.33 9.6 PDSP Ki database
α1B A0A4X1U0M4 Pig Adrenoceptors A pKi 9.8 9.8 9.8 PDSP Ki database
α1A ADA1A Japanese rice fish Adrenoceptors A pKi 9.7 9.7 9.7 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
D4 DRD4 Human Dopamine A pKi 8.29 8.29 8.29 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
μ OPRM Rat Opioid A pKi 8.01 8.01 8.01 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α2A ADA2A Pig Adrenoceptors A pKi 8.27 8.27 8.27 Drug Central
α2A ADA2A Bovine Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2A ADA2A Rat Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.15 6.92 10.15 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α1A ADA1A Rabbit Adrenoceptors A pKd 8.3 8.3 8.3 ChEMBL
α2C ADA2C Rat Adrenoceptors A pKi 7.82 7.82 7.82 PDSP Ki database
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.08 9.08 9.08 ChEMBL
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 9.07 9.53 9.75 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.54 6.54 6.54 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 9.16 9.47 9.66 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.55 4.7 4.85 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.19 6.19 6.19 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.58 5.58 5.58 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 9.06 9.12 9.18 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.38 5.38 5.38 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 4.96 4.96 4.96 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.04 8.04 8.04 Drug Central
D2 DRD2 Rat Dopamine A pIC50 8.3 8.3 8.3 Drug Central