Propranolol

Chemical Properties

SMILES OC(COc1cccc2c1cccc2)CNC(C)C
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight 259.2

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey AQHHHDLHHXJYJD-UHFFFAOYSA-N

Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β2 ADRB2 Human Adrenoceptors A pKi 9.1 9.3 9.5 Guide to Pharmacology
β3 ADRB3 Rat Adrenoceptors A pKi 6.4 6.4 6.4 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKi 6.3 6.75 7.2 Guide to Pharmacology
β3 ADRB3 Mouse Adrenoceptors A pKi 6.5 6.55 6.6 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.1 5.1 5.1 Guide to Pharmacology
β1 ADRB1 Human Adrenoceptors A pKi 8.2 8.55 8.9 Guide to Pharmacology
β1 ADRB1 Mouse Adrenoceptors A pKi 8.62 8.62 8.62 ChEMBL
β2 ADRB2 Bovine Adrenoceptors A pKd 9.05 9.05 9.05 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pKd 8.75 8.75 8.75 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pIC50 7.77 7.77 7.77 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pKd 5.58 7.73 8.62 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pKi 5.01 7.51 8.52 ChEMBL
β1 B0FL73 Guinea pig Adrenoceptors A pKd 6.6 8.31 8.76 ChEMBL
β1 B0FL73 Guinea pig Adrenoceptors A pIC50 7.46 7.46 7.46 ChEMBL
β2 ADRB2 Guinea pig Adrenoceptors A pKd 6.62 8.3 9.01 ChEMBL
β2 ADRB2 Guinea pig Adrenoceptors A pIC50 7.54 7.54 7.54 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 7.3 7.46 7.77 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.39 5.39 5.39 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.09 5.09 5.09 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 6.6 8.05 8.72 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 7.93 8.68 8.96 ChEMBL
β1 ADRB1 Human Adrenoceptors A pEC50 8.74 8.74 8.74 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKd 6.7 7.89 8.74 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKd 6.67 6.73 6.79 ChEMBL
β3 ADRB3 Human Adrenoceptors A pIC50 6.78 6.83 6.88 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 6.91 6.96 7.0 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.39 6.43 6.47 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.58 6.62 6.66 ChEMBL
D2 DRD2 Rat Dopamine A pKi 4.89 4.89 4.89 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKd 6.82 8.95 10.0 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 7.3 8.9 9.45 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 8.43 9.15 9.61 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.86 7.04 7.26 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.61 6.76 6.91 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.51 5.75 6.0 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.85 6.09 6.33 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.85 5.97 6.14 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 5.64 5.75 5.86 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 5.4 5.4 5.4 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 5.72 5.78 5.83 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.27 6.32 6.38 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.61 5.9 6.19 PDSP KiDatabase
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 5.48 5.48 5.48 PDSP KiDatabase
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL
5-HT2C 5HT2C Mouse 5-Hydroxytryptamine A pKi 5.24 5.24 5.24 PDSP KiDatabase
5-HT2C A0A4X1VZZ6 Pig 5-Hydroxytryptamine A pKi 4.8 5.31 5.8 PDSP KiDatabase
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 4.61 4.9 5.24 PDSP KiDatabase
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.07 6.45 7.3 PDSP KiDatabase
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 4.0 4.35 4.5 PDSP KiDatabase
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 4.26 4.34 4.43 PDSP KiDatabase
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 4.21 4.74 5.23 PDSP KiDatabase
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 4.6 4.6 4.6 PDSP KiDatabase
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.05 4.45 4.82 PDSP KiDatabase
D1 DRD1 Human Dopamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
D2 DRD2 Human Dopamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.48 5.86 6.26 PDSP KiDatabase
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 4.0 5.04 6.25 PDSP KiDatabase
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 4.89 4.89 4.89 PDSP KiDatabase
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
β1 ADRB1 Human Adrenoceptors A pKi 7.57 8.34 9.7 PDSP KiDatabase
β2 ADRB2 Human Adrenoceptors A pKi 8.1 8.68 10.0 PDSP KiDatabase
H1 HRH1 Human Histamine A pKi 4.0 4.11 4.22 PDSP KiDatabase
β2 ADRB2 Rat Adrenoceptors A pKi 4.0 6.65 8.34 PDSP KiDatabase
β1 H0W3H1 Guinea pig Adrenoceptors A pKi 7.28 7.28 7.28 PDSP KiDatabase
β2 ADRB2 Guinea pig Adrenoceptors A pKi 8.08 8.09 8.1 PDSP KiDatabase
β2 ADRB2 Dog Adrenoceptors A pKi 5.4 6.54 7.68 PDSP KiDatabase
D1 DRD1 Bovine Dopamine A pKi 4.0 4.0 4.0 PDSP KiDatabase
D2 DRD2 Bovine Dopamine A pKi 4.55 4.55 4.55 PDSP KiDatabase
5-HT1A 5HT1A Bornean orangutan 5-Hydroxytryptamine A pKi 6.11 6.11 6.11 PDSP KiDatabase
5-HT1B 5HT1B Guinea pig 5-Hydroxytryptamine A pKi 4.56 4.56 4.56 PDSP KiDatabase
β3 ADRB3 Human Adrenoceptors A pKi 5.73 5.73 5.73 PDSP KiDatabase
β1 ADRB1 Rat Adrenoceptors A pKi 7.55 7.86 8.16 PDSP KiDatabase
α2A ADA2A Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP KiDatabase
α2B ADA2B Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP KiDatabase
α2C ADA2C Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP KiDatabase