GPCRdb

pentoxifylline

Agent/drug
Bioactivity

pentoxifylline

SMILES	CC(=O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
InChIKey	BYPFEZZEUUWMEJ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	278.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Rat	Adenosine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A₁	AA1R	Bovine	Adenosine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A_2B	AA2BR	Human	Adenosine	A	pKi	5.29	5.29	5.29	Guide to Pharmacology
A_2B	AA2BR	Human	Adenosine	A	pKi	5.29	5.29	5.29	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	8.28	8.28	8.28	Drug Central

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.15	7.15	7.15	ChEMBL
RXFP1	RXFP1	Human	Relaxin family peptide	A	Potency	4.75	4.78	4.80	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.70	4.80	ChEMBL

Showing 1 to 3 of 3 entries

pentoxifylline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 24

Phase II 38

Phase III 20

Phase IV 2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Acute ischaemic heart disease, unspecified	2	BA4Z	R03D, C04A	0.389
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Acute kidney failure, stage unspecified	2	GB60.Z	R03D, C04A	0.516
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Acute pancreatitis, unspecified	1	DC31.Z	R03D, C04A	0.018
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Alcoholic hepatitis, unspecified	3	DB94.1Z	R03D, C04A	0.483
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Anaemias or other erythrocyte disorders, unspecified	1	3A9Z	R03D, C04A	0.042
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Behçet disease	2	4A62	R03D, C04A	0.092
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Biliary atresia	2	LB20.21	R03D, C04A	0.074
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Bipolar type I disorder, unspecified	1	6A60.Z	R03D, C04A	0.021
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Brachial plexus disorders, unspecified	3	8B91.Z	R03D, C04A	0.259
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	COVID-19	1	RA01	R03D, C04A	0.094
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Chronic kidney disease, stage unspecified	3	GB61.Z	R03D, C04A	0.507
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Crohn disease, unspecified site	1	DD70.Z	R03D, C04A	0.381
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Cutaneous leishmaniasis	2	1F54.1	R03D, C04A	0.092
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Depressive disorders, unspecified	1	6A7Z	R03D, C04A	0.048
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Diseases of coronary artery, unspecified	2	BA8Z	R03D, C04A	0.512
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	R03D, C04A	0.527
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Duchenne muscular dystrophy	1	8C70.1	R03D, C04A	0.046
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Endometriosis of unspecified site	3	GA10.Z	R03D, C04A	0.259
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Hepatic cirrhosis	3	DB93.1	R03D, C04A	0.259
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1	1C62.Z	R03D, C04A	0.383

Showing 1 to 20 of 78 entries

Join us

Cite us

Main reference

pentoxifylline

pentoxifylline

Chemical Properties

Database connections

Bioactivities

pentoxifylline

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information