Quisqualate

Chemical Properties

SMILES OC(=O)[C@H](Cn1oc(=O)[nH]c1=O)N
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 3
Molecular weight 189.0

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey ASNFTDCKZKHJSW-REOHCLBHSA-N

Database Connections

External Links
Structure pdb 7FD8 7DGE 6N51

Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 7.5 7.75 8.0 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKd 7.5 7.6 7.7 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.5 7.5 7.5 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 4.4 4.4 4.4 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 4.4 4.4 4.4 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 4.79 5.87 6.7 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.0 8.0 8.0 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 6.7 6.7 6.7 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.96 5.96 5.96 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 7.75 7.75 7.75 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 6.52 6.64 6.7 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.26 7.26 7.26 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 6.2 6.51 6.82 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase
mGlu3 GRM3 Human Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase
mGlu6 GRM6 Human Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase
mGlu5 GRM5 Human Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 4.0 4.0 4.0 PDSP KiDatabase