prochlorperazine
| SMILES | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 |
| InChIKey | WIKYUJGCLQQFNW-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 373.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 7.11 | 7.11 | 7.11 | Guide to Pharmacology |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.44 | 8.44 | 8.44 | Guide to Pharmacology |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.35 | 8.35 | 8.35 | Guide to Pharmacology |
| D4 | DRD4 | Human | Dopamine | A | pKi | 6.09 | 6.09 | 6.09 | Guide to Pharmacology |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.92 | 5.92 | 5.92 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 7.31 | 7.31 | 7.31 | ChEMBL |
| 5-HT4 | 5HT4R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 6.71 | 6.71 | 6.71 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.89 | 7.89 | 7.89 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.8 | 7.8 | 7.8 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.32 | 8.32 | 8.32 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 6.8 | 6.8 | 6.8 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.92 | 7.92 | 7.92 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 6.72 | 6.72 | 6.72 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.55 | 8.55 | 8.55 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.49 | 6.49 | 6.49 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pKi | 6.09 | 6.09 | 6.09 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.26 | 6.26 | 6.26 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.2 | 7.2 | 7.2 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 7.11 | 7.11 | 7.11 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.91 | 6.91 | 6.91 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.19 | 7.19 | 7.19 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.96 | 5.96 | 5.96 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.39 | 7.39 | 7.39 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.61 | 6.61 | 6.61 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.35 | 8.35 | 8.35 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.7 | 8.7 | 8.7 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.44 | 8.44 | 8.44 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.23 | 5.23 | 5.23 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.82 | 7.98 | 8.14 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.83 | 6.83 | 6.83 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 6.71 | 6.71 | 6.71 | PDSP Ki database |
| 5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 6.91 | 7.0 | 7.1 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.15 | 8.77 | 9.7 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.47 | 8.61 | 8.74 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.72 | 7.72 | 7.72 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.91 | 6.91 | 6.91 | PDSP Ki database |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 7.46 | 7.46 | 7.46 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 8.3 | 8.32 | 8.33 | PDSP Ki database |
| D4 | DRD4 | Human | Dopamine | A | pKi | 5.95 | 7.3 | 8.27 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 5.17 | 5.17 | 5.17 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.11 | 6.11 | 6.11 | PDSP Ki database |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.85 | 5.85 | 5.85 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT4 | 5HT4R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.83 | 6.83 | 6.83 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.58 | 5.58 | 5.58 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 7.05 | 7.05 | 7.05 | ChEMBL |
| 5-HT4 | 5HT4R | Guinea pig | 5-Hydroxytryptamine | A | pIC50 | 5.93 | 5.93 | 5.93 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 7.5 | 7.5 | 7.5 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 5.25 | 5.25 | 5.25 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 7.47 | 7.47 | 7.47 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 8.0 | 8.0 | 8.0 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.66 | 6.66 | 6.66 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 7.09 | 7.09 | 7.09 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.87 | 5.87 | 5.87 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 7.62 | 7.62 | 7.62 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.82 | 5.82 | 5.82 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pIC50 | 5.64 | 5.64 | 5.64 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 6.02 | 6.02 | 6.02 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.77 | 6.77 | 6.77 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.81 | 6.81 | 6.81 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 6.57 | 6.57 | 6.57 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 6.99 | 6.99 | 6.99 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.51 | 5.51 | 5.51 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 7.11 | 7.11 | 7.11 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.99 | 5.99 | 5.99 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 7.89 | 7.89 | 7.89 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 8.15 | 8.15 | 8.15 | ChEMBL |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 4.6 | 4.67 | 4.8 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 7.96 | 7.96 | 7.96 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.22 | 8.22 | 8.22 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.13 | 8.13 | 8.13 | Drug Central |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.5 | 5.5 | 5.5 | ChEMBL |