GPCRdb

promazine

Agent/drug
Bioactivity

promazine

SMILES	CN(C)CCCN1c2ccccc2Sc2ccccc21
InChIKey	ZGUGWUXLJSTTMA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	284.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.43	8.43	8.43	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.34	8.34	8.34	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.90	6.90	6.90	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.43	7.43	7.43	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.53	5.53	5.53	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.80	7.80	7.80	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.66	6.66	6.66	ChEMBL

Showing 1 to 20 of 54 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.03	8.03	8.03	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.10	8.10	8.10	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.09	8.09	8.09	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.89	7.89	7.89	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.47	6.47	6.47	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.75	7.75	7.75	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.60	6.60	6.60	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.29	5.29	5.29	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.28	8.28	8.28	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.64	7.64	7.64	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.46	6.46	6.46	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.00	7.00	7.00	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	6.56	6.56	6.56	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.61	5.61	5.61	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.30	6.30	6.30	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.69	6.69	6.69	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	5.90	5.90	5.90	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	5.61	7.04	8.46	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.23	8.23	8.23	Drug Central
H₂	HRH2	Human	Histamine	A	pIC50	5.54	5.54	5.54	ChEMBL

Showing 1 to 20 of 28 entries

promazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.