(R)-UH 301


SMILES CCCN([C@@H]1CCc2c(C1)c(O)ccc2F)CCC
InChIKey FNKBVTBXFLSTPB-GFCCVEGCSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 265.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pKd 9.0 9.0 9.0 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.9 8.9 8.9 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.22 8.22 8.22 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 7.85 7.85 7.85 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 7.98 7.98 7.98 Guide to Pharmacology