SB269970


SMILES CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
InChIKey HWKROQUZSKPIKQ-MRXNPFEDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations 5-HT7

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC4 MC4R Human Melanocortin A pIC50 8.1 8.1 8.1 Guide to Pharmacology
MC4 MC4R Rat Melanocortin A pEC50 5.3 5.3 5.3 ChEMBL
MC4 MC4R Rat Melanocortin A pIC50 5.52 5.52 5.52 ChEMBL
MC4 MC4R Mouse Melanocortin A pIC50 5.52 5.52 5.52 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 5.22 5.22 5.22 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 6.03 6.03 6.03 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 4.96 5.71 7.96 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 5.1 6.12 8.1 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 6.03 6.03 6.03 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 6.07 6.07 6.07 ChEMBL