SB269970


SMILES CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
InChIKey HWKROQUZSKPIKQ-MRXNPFEDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations 5-HT7

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 9.6 9.6 9.6 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 8.62 8.62 8.62 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.69 6.69 6.69 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.5 9.5 9.5 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.5 7.5 7.5 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database