GPCRdb

quetiapine

Agent/drug
Bioactivity

quetiapine

SMILES	OCCOCCN1CCN(C2=Nc3ccccc3Sc3ccccc32)CC1
InChIKey	URKOMYMAXPYINW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	383.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.46	7.46	7.46	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.00	7.35	7.70	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.87	7.87	7.87	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.00	7.00	7.00	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.41	7.41	7.41	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.32	7.32	7.32	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.66	7.66	7.66	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.03	6.03	6.03	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.44	5.49	5.65	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.26	8.26	8.26	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.00	6.67	7.34	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.13	6.36	7.05	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	7.11	7.21	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.46	7.27	7.54	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.15	5.30	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central

Showing 1 to 20 of 118 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.06	7.06	7.06	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.15	8.15	8.15	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.15	8.15	8.15	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.61	7.61	7.61	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.01	7.01	7.01	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.60	5.60	5.60	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.00	7.00	7.00	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.38	6.38	6.38	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	8.20	8.20	8.20	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.85	5.85	5.85	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	8.17	8.17	8.17	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.93	6.93	6.93	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.15	8.15	8.15	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.67	6.67	6.67	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	8.19	8.19	8.19	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.48	5.48	5.48	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.15	8.15	8.15	Drug Central
D₁	DRD1	Human	Dopamine	A	pIC50	6.37	6.37	6.37	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.48	6.48	6.48	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.88	5.88	5.88	ChEMBL

Showing 1 to 20 of 30 entries

quetiapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 9

Phase II 21

Phase III 40

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05A	0.268	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z	N05A	0.508	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N05A	0.575	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N05A	0.582	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type II disorder, unspecified	6A61.Z	N05A	0.529	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	N05A	0.406	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.588	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dementia, unknown or unspecified cause	6D8Z	N05A	0.575	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N05A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Drug-induced dystonia	8A02.10	N05A	0.385	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Generalised anxiety disorder	6B00	N05A	0.392	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Harmful pattern of use of alcohol, unspecified	6C40.1Z	N05A	0.475	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Insomnia disorders, unspecified	7A0Z	N05A	0.564	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms	6E20	N05A	0.285	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Mood disorders, unspecified	6A8Z	N05A	0.490	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Multiple sclerosis, unspecified	8A40.Z	N05A	0.047	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z	N05A	0.561	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obstructive sleep apnoea	7A41	N05A	0.050	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified depressive disorders	6A7Y	N05A	0.552	3	Yes

Showing 1 to 20 of 90 entries

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quetiapine

quetiapine

Chemical Properties

Database connections

Bioactivities

quetiapine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information