GPCRdb

raloxifene

Agent/drug
Bioactivity

raloxifene

SMILES	O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12
InChIKey	GZUITABIAKMVPG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	473.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.05	6.05	6.05	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.83	5.83	5.83	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.32	6.32	6.32	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.21	6.21	6.21	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.77	5.77	5.77	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.97	6.97	6.97	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
δ	OPRD	Human	Opioid	A	pKi	5.63	5.63	5.63	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	8.25	8.25	8.25	Drug Central
κ	OPRK	Human	Opioid	A	pKi	6.19	6.19	6.19	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.21	8.21	8.21	Drug Central
μ	OPRM	Human	Opioid	A	pKi	6.32	6.32	6.32	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.07	6.07	6.07	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 20 of 39 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.66	5.66	5.66	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.25	8.25	8.25	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.57	5.57	5.57	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.01	6.01	6.01	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.78	5.78	5.78	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.43	5.43	5.43	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.13	6.13	6.13	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	5.18	5.18	5.18	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.79	5.79	5.79	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.93	5.93	5.93	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.73	5.73	5.73	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.84	5.84	5.84	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.45	6.45	6.45	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.93	5.93	5.93	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	5.68	5.68	5.68	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.41	5.41	5.41	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.93	5.93	5.93	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.80	5.80	5.80	ChEMBL
GPER	GPER1	Human	Estrogen (G protein-coupled)	A	pEC50	8.19	8.19	8.19	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 20 of 23 entries

raloxifene

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.