GPCRdb

ritanserin

Agent/drug
Bioactivity

ritanserin

SMILES	Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey	JUQLTPCYUFPYKE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	477.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	6BQH
Ligand site mutations	5-HT_1A 5-HT_2A 5-HT_2C 5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.40	8.40	8.40	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.76	6.76	6.76	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.00	8.00	8.00	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.22	6.22	6.22	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.80	7.80	7.80	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.43	6.43	6.43	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.18	6.18	6.18	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.43	6.43	6.43	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.84	5.84	5.84	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	6.46	6.46	6.46	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	6.60	6.60	6.60	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.72	5.91	6.26	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.53	5.53	5.53	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.55	6.55	6.55	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.41	6.24	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.54	6.56	6.58	PDSP Ki database
5-HT_1B	5HT1B	Guinea pig	5-Hydroxytryptamine	A	pKi	6.43	6.43	6.43	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.44	6.29	7.14	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.60	7.60	7.60	Guide to Pharmacology

Showing 1 to 20 of 62 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.33	7.33	7.33	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.35	5.35	5.35	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	5.20	5.35	5.50	Guide to Pharmacology
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	6.00	6.25	6.50	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pIC50	7.64	7.88	7.92	ChEMBL
FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.25	5.25	5.25	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	5.15	5.50	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.70	5.50	6.30	ChEMBL
TAS2R20	T2R20	Human	Taste 2	T2	pEC50	5.22	5.22	5.22	Guide to Pharmacology
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 10 of 10 entries

ritanserin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	6BQH
Ligand site mutations	5-HT_1A 5-HT_2A 5-HT_2C 5-HT₆

Compound is not listed as a drug.