pobilukast


SMILES OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O
InChIKey PZIFPMYXXCAOCC-JWQCQUIFSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 16
Molecular weight (Da) 458.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 10.0 10.0 10.0 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.7 5.7 5.7 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.9 5.9 5.9 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.8 5.8 5.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.5 6.5 6.5 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 8.7 10.45 12.2 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 6.5 6.5 6.5 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.0 7.0 7.0 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 5.6 5.6 5.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database