SDZ 205557


SMILES CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC
InChIKey FFNWMBDISAYHDC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 300.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 7.6 7.65 7.7 Guide to Pharmacology
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Guide to Pharmacology
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 8.26 8.27 8.28 ChEMBL
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 7.6 7.67 7.7 PDSP Ki database
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 8.11 8.18 8.2 PDSP Ki database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 8.1 8.24 8.6 PDSP Ki database
μ OPRM Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 PDSP Ki database
5-HT1D A0A4W2F4L6 Hybrid cattle 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pIC50 6.6 6.94 7.11 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.75 4.75 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 6.4 6.4 6.4 ChEMBL