SB-706375


SMILES COc1cc(c(cc1OC)Br)S(=O)(=O)Nc1ccc(c(c1)O[C@@H]1CCN(C1)C)C(F)(F)F
InChIKey BPOWQJYAMDEAFF-CYBMUJFWSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 538.0

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
UT UR2R Human Urotensin A pKi 8.1 8.18 8.27 ChEMBL
UT UR2R Human Urotensin A pKi 8.0 8.0 8.0 Guide to Pharmacology
UT UR2R Mouse Urotensin A pKi 7.7 7.7 7.7 Guide to Pharmacology
UT UR2R Rat Urotensin A pKi 7.7 7.7 7.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
UT UR2R Rat Urotensin A pIC50 7.47 7.47 7.47 ChEMBL
UT UR2R Human Urotensin A pIC50 7.85 8.06 8.22 ChEMBL