ST-1006


SMILES CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N
InChIKey ICAQZJCLBRKWBG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 366.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pKi 7.92 7.93 7.94 ChEMBL
H1 HRH1 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H2 HRH2 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 6.29 6.29 6.29 ChEMBL
H3 HRH3 Human Histamine A pKi 6.29 6.29 6.29 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 7.9 7.9 7.9 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pEC50 8.85 8.9 8.95 ChEMBL