GPCRdb

sparsentan

Agent/drug
Bioactivity

sparsentan

SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	1
Rotatable bonds	12
Molecular weight (Da)	592.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

No bioactivity data available.

sparsentan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 4

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09X	0.708	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Nephritic syndrome	GB40	C09X	0.366	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified clinical findings in specimens from the urinary system	MF8Y	C09X	0.356	3	Yes
EDNRA	ET_A receptor	Endothelin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09X	0.365	2	Yes
EDNRA	ET_A receptor	Endothelin receptors	Peptide receptors	Class A	Nephritic syndrome	GB40	C09X	0.475	4	Yes
EDNRA	ET_A receptor	Endothelin receptors	Peptide receptors	Class A	Other specified clinical findings in specimens from the urinary system	MF8Y	C09X	0.290	3	Yes

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