spiperone


SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
InChIKey DKGZKTPJOSAWFA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 395.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7DFP
Ligand site mutations α1A α1B 5-HT1A 5-HT2A D1 D2 D3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.5 5.75 6.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.8 8.6 9.4 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 9.0 9.1 9.2 Guide to Pharmacology
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.6 5.9 6.2 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.0 7.5 8.0 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 8.3 8.3 8.3 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 8.1 8.1 8.1 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 6.7 6.7 6.7 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 9.3 9.3 9.3 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKd 9.5 9.5 9.5 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 5.3 5.3 5.3 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.7 7.85 8.0 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 8.4 8.9 9.4 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKd 10.2 10.2 10.2 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKd 9.9 9.9 9.9 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 7.87 7.87 7.87 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.7 7.8 8.0 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.8 5.9 6.0 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 4.2 4.2 4.2 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.32 5.32 5.32 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 8.89 8.89 8.89 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.15 8.15 8.15 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.42 7.78 8.14 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.96 7.12 7.7 ChEMBL
D2 DRD2 Rat Dopamine A pKi 9.24 9.88 10.82 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.85 9.35 9.7 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.1 8.1 8.1 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.22 7.21 7.6 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.49 6.49 6.49 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.94 6.07 6.2 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.88 9.47 9.92 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.53 8.7 8.96 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 7.4 7.4 7.4 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.76 7.76 7.76 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.92 9.7 10.22 ChEMBL
D2 DRD2 Human Dopamine A pKd 9.8 9.8 9.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.96 6.12 6.3 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.39 5.89 6.1 PDSP Ki database
5-HT2C 5HT2C Mouse 5-Hydroxytryptamine A pKi 6.29 6.29 6.29 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.7 6.04 7.21 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.37 7.04 7.76 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.37 7.22 7.71 PDSP Ki database
5-HT1A F6Q2H9 Bovine 5-Hydroxytryptamine A pKi 6.81 7.22 7.64 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 7.18 7.21 7.32 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 5.4 6.0 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 5.24 5.3 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.14 5.32 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.3 8.65 9.42 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.4 9.08 9.92 PDSP Ki database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 8.85 8.85 8.85 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 PDSP Ki database
5-HT2B F6QI78 Bovine 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.7 7.88 8.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.24 6.45 6.66 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 9.36 10.03 10.52 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 9.15 9.53 9.7 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.0 5.5 6.0 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 7.21 7.21 7.21 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 9.41 9.86 10.3 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.18 9.88 10.7 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.8 6.05 6.5 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.0 5.41 5.52 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 6.67 7.0 7.32 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 PDSP Ki database
D2 A0A287B0Q7 Pig Dopamine A pKi 9.72 10.11 10.52 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.0 6.7 8.4 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.4 9.17 10.1 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 8.88 9.19 9.49 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.18 6.35 6.57 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 6.17 6.17 6.17 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 5.08 5.77 6.45 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 9.6 9.6 9.6 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.85 5.94 6.12 PDSP Ki database
5-HT1D 5HT1D Dog 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT2B 5HT2B Mouse 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.35 5.35 5.35 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 9.96 10.48 11.0 PDSP Ki database
α1B A0A4X1U0M4 Pig Adrenoceptors A pKi 8.3 8.3 8.3 PDSP Ki database
α1A Q9TSW7 Pig Adrenoceptors A pKi 7.2 7.8 8.3 PDSP Ki database
5-HT1A A0A286Y074 Guinea pig 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 6.44 6.44 6.44 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 8.51 8.51 8.51 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 7.69 7.88 8.08 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.57 5.57 5.57 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 4.2 4.2 4.2 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 8.13 8.13 8.13 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.06 8.06 8.06 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.38 8.38 8.38 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
D1 DRD1 Human Dopamine A pKi 8.19 8.19 8.19 Drug Central
D2 DRD2 Human Dopamine A pKi 7.99 7.99 7.99 Drug Central
D3 DRD3 Human Dopamine A pKi 8.0 8.0 8.0 Drug Central
D4 DRD4 Human Dopamine A pKi 8.01 8.01 8.01 Drug Central
D5 DRD5 Human Dopamine A pKi 8.28 8.28 8.28 Drug Central
H1 HRH1 Human Histamine A pKi 8.2 8.2 8.2 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.05 8.05 8.05 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 Drug Central
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
D2 DRD2 Rat Dopamine A pKi 7.97 7.97 7.97 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.7 7.75 8.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 6.2 6.5 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 9.2 9.2 9.2 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 6.0 6.0 6.0 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.0 5.22 5.45 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 6.51 6.51 6.51 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 10.22 10.22 10.22 ChEMBL
D4 DRD4 Human Dopamine A pIC50 9.3 9.3 9.3 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.91 6.91 6.91 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.01 7.83 9.44 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.25 8.25 8.25 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.59 9.03 9.6 ChEMBL
D2 DRD2 Human Dopamine A pEC50 8.85 8.85 8.85 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.6 5.6 5.6 ChEMBL