endomorphin-2


SMILES None
InChIKey XIJHWXXXIMEHKW-LJWNLINESA-N
Sequence YPFF

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKi 8.5 8.5 8.5 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.97 7.97 7.97 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.11 5.34 5.57 ChEMBL
μ OPRM Rat Opioid A pKi 7.72 8.53 9.31 ChEMBL
δ OPRD Human Opioid A pKi 5.1 5.24 5.47 ChEMBL
κ OPRK Human Opioid A pKi 5.28 5.62 5.95 ChEMBL
μ OPRM Human Opioid A pKi 8.09 8.57 9.16 ChEMBL
μ OPRM Rat Opioid A pKi 7.71 8.51 9.24 PDSP Ki database
μ OPRM Mouse Opioid A pKi 8.8 8.83 8.86 PDSP Ki database
μ OPRM Bovine Opioid A pKi 9.37 9.37 9.37 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.3 6.3 6.3 PDSP Ki database
δ F1N083 Bovine Opioid A pKi 6.3 6.3 6.3 PDSP Ki database
NK1 NK1R Rat Tachykinin A pKi 7.52 7.88 8.06 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pIC50 7.62 7.7 7.78 ChEMBL
δ OPRD Mouse Opioid A pIC50 6.29 6.93 7.82 ChEMBL
μ OPRM Rat Opioid A pIC50 8.46 9.0 9.16 ChEMBL
μ OPRM Rat Opioid A pEC50 6.42 6.73 7.11 ChEMBL
μ OPRM Human Opioid A pEC50 7.2 8.25 10.4 ChEMBL