TFMPP


SMILES FC(c1cccc(c1)N1CCNCC1)(F)F
InChIKey KKIMDKMETPPURN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 230.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.53 7.41 8.65 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.71 6.62 7.09 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.79 7.07 7.5 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.13 6.84 7.49 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.61 7.17 7.56 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.2 6.55 6.9 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.68 6.97 7.19 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.1 7.15 7.2 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.2 5.55 6.24 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.2 5.3 5.4 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.54 7.06 7.4 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.13 7.48 7.84 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.5 7.15 7.8 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.37 6.37 6.37 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.32 6.32 6.32 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.52 7.09 7.66 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.49 6.76 7.12 PDSP Ki database
5-HT1F 5HT1F Mouse 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 PDSP Ki database
5-HT1D 5HT1D Dog 5-Hydroxytryptamine A pKi 6.95 6.95 6.95 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.36 7.35 8.49 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 6.28 6.85 7.23 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.27 6.45 6.63 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.3 6.45 6.6 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.07 7.07 7.07 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 6.17 6.43 6.82 PDSP Ki database
5-HT1A F6Q2H9 Bovine 5-Hydroxytryptamine A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 6.92 7.19 7.3 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 7.29 7.43 7.57 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.54 6.54 6.54 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 6.21 6.21 6.21 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.82 6.82 6.82 ChEMBL