GPCRdb

tamoxifen

Agent/drug
Bioactivity

tamoxifen

SMILES	CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
InChIKey	NKANXQFJJICGDU-QPLCGJKRSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	8
Molecular weight (Da)	371.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	5.05	5.05	5.05	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.61	5.61	5.61	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.25	8.25	8.25	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.14	6.14	6.14	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.79	5.79	5.79	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.24	5.24	5.24	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Human	Opioid	A	pKi	5.33	5.33	5.33	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	8.27	8.27	8.27	Drug Central
κ	OPRK	Human	Opioid	A	pKi	5.20	5.20	5.20	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.28	8.28	8.28	Drug Central
μ	OPRM	Human	Opioid	A	pKi	5.15	5.15	5.15	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.16	5.16	5.16	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.86	5.86	5.86	ChEMBL

Showing 1 to 20 of 66 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	4.66	4.66	4.66	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.33	8.33	8.33	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.30	5.30	5.30	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.71	5.71	5.71	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.45	5.45	5.45	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	4.76	4.76	4.76	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.11	5.11	5.11	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	4.88	4.88	4.88	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	4.81	4.81	4.81	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	4.75	4.75	4.75	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	4.92	4.92	4.92	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.31	8.31	8.31	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.32	5.32	5.32	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.68	5.68	5.68	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.34	6.34	6.34	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.57	5.57	5.57	ChEMBL
A₁	AA1R	Human	Adenosine	A	pIC50	4.62	4.62	4.62	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	5.15	5.15	5.15	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	5.43	5.43	5.43	ChEMBL
B₂	BKRB2	Human	Bradykinin	A	pIC50	4.69	4.69	4.69	ChEMBL

Showing 1 to 20 of 37 entries

tamoxifen

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology GPCRdb

Compound is not listed as a drug.