vibegron


SMILES O=C([C@@H]1CCc2n1c(=O)ccn2)Nc1ccc(cc1)C[C@@H]1CC[C@@H](N1)[C@@H](c1ccccc1)O
InChIKey DJXRIQMCROIRCZ-XOEOCAAJSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 444.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β3 ADRB3 Human Adrenoceptors A pEC50 8.96 8.96 8.96 Guide to Pharmacology
β3 ADRB3 Rat Adrenoceptors A pEC50 7.07 7.07 7.07 Guide to Pharmacology
β3 ADRB3 Rhesus macaque Adrenoceptors A pEC50 8.15 8.7 9.24 ChEMBL
β3 ADRB3 Human Adrenoceptors A pEC50 8.8 8.88 8.96 ChEMBL
β3 ADRB3 Human Adrenoceptors A pEC50 8.05 8.05 8.05 Drug Central
β3 ADRB3 Dog Adrenoceptors A pEC50 8.1 8.1 8.1 Drug Central
β3 ADRB3 Rat Adrenoceptors A pEC50 8.15 8.15 8.15 Drug Central
β3 ADRB3 Rhesus macaque Adrenoceptors A pEC50 8.03 8.03 8.03 Drug Central
β3 ADRB3 Dog Adrenoceptors A pEC50 7.96 7.96 7.96 ChEMBL
β3 ADRB3 Rat Adrenoceptors A pEC50 6.91 6.99 7.07 ChEMBL