GPCRdb

tecalcet

Agent/drug
Bioactivity

tecalcet

SMILES	COc1cccc([C@@H](C)NCCCc2ccccc2Cl)c1
InChIKey	ZVQUCWXZCKWZBP-CQSZACIVSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	303.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	7SIL 9AXF 9ASB 9AVG 9AYF 9AVL
Ligand site mutations	CaS

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.02	6.02	6.02	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.80	5.80	5.80	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.85	5.85	5.85	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	5.66	5.66	5.66	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.84	5.84	5.84	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.74	6.74	6.74	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.37	7.37	7.37	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.79	6.79	6.79	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.96	5.96	5.96	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.63	5.63	5.63	ChEMBL
CaS	CASR	Human	Calcium-sensing	C	pKd	6.50	6.50	6.50	Guide to Pharmacology
D₃	DRD3	Human	Dopamine	A	pKi	6.06	6.06	6.06	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	6.04	6.04	6.04	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	5.85	5.85	5.85	ChEMBL

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CaS	CASR	Human	Calcium-sensing	C	pKB	6.20	6.40	6.60	Guide to Pharmacology
CaS	CASR	Human	Calcium-sensing	C	pEC50	6.71	6.97	7.10	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.66	5.66	5.66	ChEMBL

Showing 1 to 3 of 3 entries

tecalcet

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	7SIL 9AXF 9ASB 9AVG 9AYF 9AVL
Ligand site mutations	CaS

Compound is not listed as a drug.