GPCRdb

telmisartan

Agent/drug
Bioactivity

telmisartan

SMILES	CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
InChIKey	RMMXLENWKUUMAY-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	514.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTRA	Rat	Angiotensin	A	pKi	9.64	9.64	9.64	ChEMBL
AT₁	AGTRA	Rat	Angiotensin	A	pKi	8.02	8.02	8.02	Drug Central

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.40	8.40	8.40	Guide to Pharmacology
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.52	8.52	8.52	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	6.82	8.66	9.31	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.03	8.03	8.03	Drug Central
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.07	8.07	8.07	Drug Central
AT₂	AGTR2	Human	Angiotensin	A	pIC50	8.02	8.02	8.02	Drug Central
AT₂	AGTR2	Human	Angiotensin	A	pIC50	9.48	9.48	9.48	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.90	5.90	5.90	ChEMBL

Showing 1 to 8 of 8 entries

telmisartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 3

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C09D, C09C	0.474	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Alzheimer disease	8A20	C09D, C09C	0.273	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	COVID-19	RA01	C09D, C09C	0.554	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	C09D, C09C	0.595	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09D, C09C	0.708	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1C62.Z	C09D, C09C	0.246	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Inborn errors of lipid metabolism, unspecified	5C52.Z	C09D, C09C	0.353	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	C09D, C09C	0.074	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Obstructive sleep apnoea	7A41	C09D, C09C	0.011	1	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Proteinuria, unspecified	MF96.Z	C09D, C09C	0.507	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	C09D, C09C	0.605	4	Yes

Showing 1 to 11 of 11 entries