GPCRdb

terfenadine

Agent/drug
Bioactivity

terfenadine

SMILES	CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
InChIKey	GUGOEEXESWIERI-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	8
Molecular weight (Da)	471.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.73	5.73	5.73	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.26	6.26	6.26	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.14	7.14	7.14	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.52	7.52	7.52	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.19	6.19	6.19	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.22	6.22	6.22	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
CCR5	CCR5	Human	Chemokine	A	pKi	6.07	6.07	6.07	ChEMBL
CCR5	CCR5	Human	Chemokine	A	pKi	8.22	8.22	8.22	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	5.87	5.87	5.87	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	8.23	8.23	8.23	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	5.69	5.69	5.69	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.25	8.25	8.25	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	6.29	6.29	6.29	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.20	8.20	8.20	Drug Central

Showing 1 to 20 of 28 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.48	5.48	5.48	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.43	5.43	5.43	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.59	6.59	6.59	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.32	7.32	7.32	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.91	5.91	5.91	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.88	5.88	5.88	ChEMBL
CCR5	CCR5	Human	Chemokine	A	pIC50	5.96	5.96	5.96	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.57	5.57	5.57	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.21	5.21	5.21	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.82	5.82	5.82	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	6.53	6.78	7.03	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.25	7.64	9.00	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.95	5.03	5.10	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.54	5.54	5.54	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	8.26	8.26	8.26	Drug Central
NK₂	NK2R	Human	Tachykinin	A	pIC50	5.57	5.57	5.57	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL

Showing 1 to 17 of 17 entries

terfenadine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	H₁

Compound is not listed as a drug.