tryptamine


SMILES NCCc1c[nH]c2c1cccc2
InChIKey APJYDQYYACXCRM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 160.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Ligand site mutations 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.77 6.77 6.77 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.75 6.96 7.16 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.48 7.63 7.79 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 6.53 7.15 7.44 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.98 6.98 6.98 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.28 6.68 7.07 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.44 7.44 7.44 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.28 7.02 7.38 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.21 7.42 7.64 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.8 7.1 7.4 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.59 5.59 5.59 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.6 6.05 6.5 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.62 5.62 5.62 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 6.1 7.05 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.5 6.55 7.6 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.99 7.31 7.6 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.63 6.65 7.34 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.6 6.4 7.2 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.36 6.36 6.36 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
TA1 TAAR1 Human Trace amine A pKi 5.96 5.96 5.96 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.83 6.33 6.8 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.8 6.3 6.8 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.11 6.78 7.25 PDSP Ki database
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.21 5.43 PDSP Ki database
5-HT2B 5HT2B Mouse 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 PDSP Ki database
5-HT1D 5HT1D Dog 5-Hydroxytryptamine A pKi 6.46 6.46 6.46 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.5 5.99 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 4.99 4.99 4.99 ChEMBL
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 7.19 7.46 7.72 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.5 7.65 7.8 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.7 6.87 6.95 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKd 6.27 6.27 6.27 ChEMBL
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
5-HT2B F6QI78 Bovine 5-Hydroxytryptamine A pKi 5.89 5.89 5.89 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.3 7.32 7.33 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TA1 TAAR1 Rat Trace amine A pEC50 6.51 6.51 6.51 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.13 8.13 8.13 ChEMBL
TA1 TAAR1 Human Trace amine A pEC50 5.66 5.66 5.66 ChEMBL