GPCRdb

trifluoperazine

Agent/drug
Bioactivity

trifluoperazine

SMILES	CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChIKey	ZEWQUBUPAILYHI-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	407.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.62	7.62	7.62	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.18	6.18	6.18	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.79	6.79	6.79	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.41	6.41	6.41	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.39	6.39	6.39	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	4.92	5.47	6.02	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.87	7.81	8.13	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.10	8.10	8.10	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.90	7.90	7.90	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.42	6.42	6.42	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.42	6.71	7.00	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.18	7.18	7.18	PDSP Ki database

Showing 1 to 20 of 51 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pIC50	7.80	7.80	7.80	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.00	5.00	5.00	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.60	4.70	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 4 of 4 entries

trifluoperazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05A	0.463	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.601	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05A	0.463	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.595	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.589	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.614	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.370	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.565	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05A	0.508	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.601	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05A	0.464	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.569	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.591	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.704	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05A	0.463	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.570	4	Yes

Showing 1 to 20 of 22 entries

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trifluoperazine

trifluoperazine

Chemical Properties

Database connections

Bioactivities

trifluoperazine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information