Ligand Data

Ligand

id 3910
Name zotepine
SMILES CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C
InChIKey HDOZVRUNCMBHFH-UHFFFAOYSA-N
Type small-molecule
External Links
Structure pdb 6A94

Structure

Properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight 331.1


Bioactivity

Receptor Affinity (nM) Potency (nM)
GTP Uniprot Species Family Class Min Avg Max Min Avg Max
H1 HRH1 Human Histamine A (Rhodopsin) 0.6 0.6 0.6
D1 DRD1 Human Dopamine A (Rhodopsin) 29.0 29.0 29.0
D4 DRD4 Human Dopamine A (Rhodopsin) 39.0 39.0 39.0
5-HT2A 5HT2A Human 5-Hydroxytryptamine A (Rhodopsin) 0.5 1.6 2.7
D3 DRD3 Human Dopamine A (Rhodopsin) 6.4 6.4 6.4
D2 DRD2 Human Dopamine A (Rhodopsin) 11.0 11.0 11.0