TAK 044
| SMILES | None |
| InChIKey | UOZMDLYHZJQAOO-YHIUFLQMSA-N |
| Sequence | DDDXLW |
Chemical properties
| Hydrogen bond acceptors | None |
| Hydrogen bond donors | None |
| Rotatable bonds | None |
| Molecular weight (Da) |
Drug properties
| Molecular type | Peptide |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKd | 9.19 | 9.19 | 9.19 | ChEMBL |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 8.81 | 8.81 | 8.81 | ChEMBL |
| V2 | V2R | Rat | Vasopressin and oxytocin | A | pKd | 8.82 | 8.82 | 8.82 | ChEMBL |
| V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 9.35 | 9.35 | 9.35 | ChEMBL |
| OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 8.93 | 8.93 | 8.93 | ChEMBL |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 8.7 | 9.06 | 9.31 | ChEMBL |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 7.5 | 8.53 | 8.92 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 7.92 | 8.48 | 8.78 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 8.4 | 9.0 | 9.59 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 8.5 | 8.9 | 9.3 | Guide to Pharmacology |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 9.0 | 9.25 | 9.5 | Guide to Pharmacology |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 7.9 | 8.5 | 9.1 | Guide to Pharmacology |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 7.3 | 8.3 | 9.3 | Guide to Pharmacology |
| V1B | V1BR | Rat | Vasopressin and oxytocin | A | pKi | 9.54 | 9.54 | 9.54 | ChEMBL |
| V1B | V1BR | Rat | Vasopressin and oxytocin | A | pKi | 9.9 | 9.9 | 9.9 | Guide to Pharmacology |
| V2 | V2R | Bovine | Vasopressin and oxytocin | A | pKd | 8.82 | 8.82 | 8.82 | ChEMBL |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| V2 | V2R | Pig | Vasopressin and oxytocin | A | pIC50 | 8.48 | 8.48 | 8.48 | ChEMBL |
| V1A | V1AR | Rat | Vasopressin and oxytocin | A | pEC50 | 10.15 | 10.18 | 10.2 | ChEMBL |
| V1B | V1BR | Human | Vasopressin and oxytocin | A | pEC50 | 8.37 | 8.45 | 8.7 | ChEMBL |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pEC50 | 10.28 | 10.29 | 10.3 | ChEMBL |
| V2 | V2R | Human | Vasopressin and oxytocin | A | pIC50 | 6.62 | 6.62 | 6.62 | ChEMBL |
| OT | OXYR | Human | Vasopressin and oxytocin | A | pEC50 | 7.39 | 8.13 | 10.0 | ChEMBL |
| V1A | V1AR | Human | Vasopressin and oxytocin | A | pEC50 | 9.62 | 9.62 | 9.63 | ChEMBL |