GPCRdb

valsartan

Agent/drug
Bioactivity

valsartan

SMILES	CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C
InChIKey	ACWBQPMHZXGDFX-QFIPXVFZSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	10
Molecular weight (Da)	435.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pKi	5.33	6.92	8.52	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	8.27	8.27	8.27	Drug Central

Showing 1 to 2 of 2 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.80	8.75	9.00	Guide to Pharmacology
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.72	8.72	8.72	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.13	8.35	8.57	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.06	8.06	8.06	Drug Central
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	8.07	8.07	8.07	Drug Central
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	8.47	8.47	8.47	ChEMBL
BLT₂	LT4R2	Human	Leukotriene	A	pEC50	4.80	4.80	4.80	ChEMBL

Showing 1 to 7 of 7 entries

valsartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 4

Phase III 10

Phase IV 6

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Acute ST elevation myocardial infarction	3	BA41.0	C09D, C09C, C10B	0.324
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Acute ischaemic heart disease, unspecified	2	BA4Z	C09D, C09C, C10B	0.081
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Acute myocardial infarction, unspecified	4	BA41.Z	C09D, C09C, C10B	0.474
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Aortic valve insufficiency, unspecified	2	BB71.Z	C09D, C09C, C10B	0.092
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Atrial fibrillation, unspecified	3	BC81.3Z	C09D, C09C, C10B	0.587
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Congestive heart failure	4	BD10	C09D, C09C, C10B	0.599
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Diseases of arteries or arterioles, unspecified	2	BD5Z	C09D, C09C, C10B	0.049
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Diseases of the urinary system, unspecified	3	GC2Z	C09D, C09C, C10B	0.317
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Essential hypertension, unspecified	4	BA00.Z	C09D, C09C, C10B	0.708
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Heart failure, unspecified	4	BD1Z	C09D, C09C, C10B	0.611
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Hypercholesterolaemia, unspecified	3	5C80.0Z	C09D, C09C, C10B	0.391
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Hypertrophic cardiomyopathy, unspecified	3	BC43.1Z	C09D, C09C, C10B	0.132
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Inborn errors of lipid metabolism, unspecified	3	5C52.Z	C09D, C09C, C10B	0.353
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Infectious myocarditis	3	BC42.1	C09D, C09C, C10B	0.259
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Other specified syndromic genetic deafness	2	LD2H.Y	C09D, C09C, C10B	0.074
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Pulmonary hypertension, unspecified	3	BB01.Z	C09D, C09C, C10B	0.329
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Stroke not known if ischaemic or haemorrhagic	4	8B20	C09D, C09C, C10B	0.605
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Type 2 diabetes mellitus	3	5A11	C09D, C09C, C10B	0.592

Showing 1 to 18 of 18 entries

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Main reference

valsartan

valsartan

Chemical Properties

Database connections

Bioactivities

valsartan

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information