GPCRdb

amiodarone

Agent/drug
Bioactivity

amiodarone

SMILES	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
InChIKey	IYIKLHRQXLHMJQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	11
Molecular weight (Da)	645.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.93	6.93	6.93	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.23	5.23	5.23	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	4.60	4.60	4.60	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	4.50	4.50	4.50	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.35	8.35	8.35	Drug Central
δ	OPRD	Human	Opioid	A	pKi	8.26	8.26	8.26	Drug Central
δ	OPRD	Human	Opioid	A	pKi	5.55	5.55	5.55	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.18	5.18	5.18	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.29	8.29	8.29	Drug Central
μ	OPRM	Human	Opioid	A	pKi	5.11	5.11	5.11	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	4.41	4.41	4.41	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.36	8.36	8.36	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.99	5.99	5.99	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.23	6.23	6.23	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.67	6.67	6.67	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central

Showing 1 to 20 of 60 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.51	6.51	6.51	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.20	8.20	8.20	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	4.89	4.89	4.89	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	4.36	4.36	4.36	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	8.33	8.33	8.33	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	4.37	4.37	4.37	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	5.10	5.10	5.10	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	4.78	4.78	4.78	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	4.72	4.72	4.72	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	4.07	4.07	4.07	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.45	5.45	5.45	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.04	6.04	6.04	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.39	6.39	6.39	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	4.71	4.71	4.71	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	4.76	4.76	4.76	ChEMBL
B₂	BKRB2	Human	Bradykinin	A	pIC50	4.89	4.89	4.89	ChEMBL
CCR2	CCR2	Human	Chemokine	A	pIC50	4.96	4.96	4.96	ChEMBL
CCR4	CCR4	Human	Chemokine	A	pIC50	4.66	4.66	4.66	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.04	5.04	5.04	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	4.70	4.70	4.70	ChEMBL

Showing 1 to 20 of 37 entries

amiodarone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 9

Phase III 9

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C01B	0.605	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	COVID-19	RA01	C01B	0.261	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiac arrhythmia, unspecified	BC9Z	C01B	0.574	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiomyopathy, unspecified	BC43.Z	C01B	0.474	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Congestive heart failure	BD10	C01B	0.600	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Infectious myocarditis	BC42.1	C01B	0.001	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified ventricular rhythm disturbance	BC7Y	C01B	0.596	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Supraventricular tachyarrhythmia, unspecified	BC81.Z	C01B	0.259	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular fibrillation	BC71.1	C01B	0.375	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular tachycardia, unspecified	BC71.0Z	C01B	0.541	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C01B	0.598	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	COVID-19	RA01	C01B	0.289	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiac arrhythmia, unspecified	BC9Z	C01B	0.564	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiomyopathy, unspecified	BC43.Z	C01B	0.077	3	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Congestive heart failure	BD10	C01B	0.594	3	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified ventricular rhythm disturbance	BC7Y	C01B	0.583	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Supraventricular tachyarrhythmia, unspecified	BC81.Z	C01B	0.259	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular fibrillation	BC71.1	C01B	0.375	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular tachycardia, unspecified	BC71.0Z	C01B	0.539	4	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C01B	0.490	4	Yes

Showing 1 to 20 of 27 entries

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amiodarone

amiodarone

Chemical Properties

Database connections

Bioactivities

amiodarone

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information