GPCRdb

LEVODOPA

Agent/drug
Bioactivity

LEVODOPA

SMILES	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O
InChIKey	WTDRDQBEARUVNC-LURJTMIESA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	3
Molecular weight (Da)	197.1

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 3 of 3 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.15	7.15	7.15	ChEMBL

Showing 1 to 1 of 1 entry

LEVODOPA

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 25

Phase II 43

Phase III 35

Approved Yes

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0		0.092	1	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.001	2	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z		0.288	3	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Impairment of binocular functions	9D46		0.026	3	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Injury of spinal cord, level unspecified	ND51.2		0.011	3	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.004	1	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z		0.588	4	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40		0.003	2	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Restless legs syndrome	7A80		0.037	3	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.508	2	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00		0.481	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Age-related macular degeneration, unspecified	9B75.0Z		0.007	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0		0.111	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Asthma	CA23		0.037	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.499	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z		0.470	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Inherited retinal dystrophies	9B70		0.001	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Injury of spinal cord, level unspecified	ND51.2		0.024	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.077	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.527	2	Yes

Showing 1 to 20 of 67 entries

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LEVODOPA

LEVODOPA

Chemical Properties

Database connections

Bioactivities

LEVODOPA

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information