apafant


SMILES O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl
InChIKey JGPJQFOROWSRRS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 455.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
PAF PTAFR Human Platelet-activating factor A pKi 5.2 6.35 7.5 Guide to Pharmacology
PAF PTAFR Human Platelet-activating factor A pKd 7.4 7.7 8.0 Guide to Pharmacology
PAF PTAFR Guinea pig Platelet-activating factor A pKi 7.01 7.39 8.15 ChEMBL
PAF PTAFR Human Platelet-activating factor A pKi 7.1 7.38 7.63 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
PAF PTAFR Guinea pig Platelet-activating factor A pIC50 6.84 6.97 7.04 ChEMBL
PAF PTAFR Human Platelet-activating factor A pIC50 6.7 6.97 7.4 ChEMBL