GPCRdb

apomorphine

Agent/drug
Bioactivity

apomorphine

SMILES	CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
InChIKey	VMWNQDUVQKEIOC-CYBMUJFWSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	0
Molecular weight (Da)	267.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7JVQ
Ligand site mutations	5-HT_2A D₂ D₃ D₅

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.20	7.20	7.20	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.40	7.40	7.40	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.53	6.53	6.53	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.27	6.56	6.93	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.92	6.92	6.92	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology

Showing 1 to 20 of 55 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Rat	Dopamine	A	pIC50	5.52	6.32	6.62	ChEMBL
D₁	DRD1	Human	Dopamine	A	pEC50	6.28	7.38	8.42	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.52	7.68	9.00	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	7.28	8.47	9.40	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	6.24	8.17	8.80	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.93	7.66	8.38	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	7.16	7.42	7.57	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.15	8.15	8.15	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pEC50	8.26	8.45	8.82	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	8.37	8.37	8.37	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pEC50	8.05	8.05	8.05	Drug Central

Showing 1 to 11 of 11 entries

apomorphine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 6

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7JVQ
Ligand site mutations	5-HT_2A D₂ D₃ D₅

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Hallucinations, unspecified	MB27.2Z	N04B, G04B	0.074	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	N04B, G04B	0.077	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Male erectile dysfunction, unspecified	HA01.1Z	N04B, G04B	0.374	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Osteoporosis, unspecified	FB83.1Z	N04B, G04B	0.046	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B, G04B	0.621	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Hallucinations, unspecified	MB27.2Z	N04B, G04B	0.075	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	N04B, G04B	0.079	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Male erectile dysfunction, unspecified	HA01.1Z	N04B, G04B	0.370	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Osteoporosis, unspecified	FB83.1Z	N04B, G04B	0.046	1	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B, G04B	0.612	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Hallucinations, unspecified	MB27.2Z	N04B, G04B	0.074	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	N04B, G04B	0.074	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Male erectile dysfunction, unspecified	HA01.1Z	N04B, G04B	0.372	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Osteoporosis, unspecified	FB83.1Z	N04B, G04B	0.046	1	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B, G04B	0.609	4	Yes

Showing 1 to 15 of 15 entries

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apomorphine

apomorphine

Chemical Properties

Database connections

Bioactivities

apomorphine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information