naratriptan


SMILES CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C
InChIKey AMKVXSZCKVJAGH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 335.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 5.7 5.7 5.7 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 5.8 5.8 5.8 ChEMBL
H1 HRH1 Guinea pig Histamine A pKd 8.9 9.02 9.13 ChEMBL
H3 HRH3 Guinea pig Histamine A pKd 5.2 5.2 5.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pEC50 6.7 6.7 6.7 ChEMBL
H4 HRH4 Human Histamine A pEC50 5.0 5.0 5.0 ChEMBL