TRIFLUPERIDOL


SMILES O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1
InChIKey GPMXUUPHFNMNDH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 409.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 9.02 9.02 9.02 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 6.13 6.13 6.13 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 6.49 7.98 9.46 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 9.4 9.55 9.7 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.38 8.42 8.46 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.01 8.01 8.01 Drug Central
D3 DRD3 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D4 DRD4 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.65 4.75 4.85 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL