Ro-70-0004


SMILES Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C
InChIKey WEZFJPKJUIGDPS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 444.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Human Adenosine A pKi 6.43 6.43 6.43 Guide to Pharmacology
A2A AA2AR Human Adenosine A pKi 6.18 6.18 6.18 Guide to Pharmacology
A2B AA2BR Human Adenosine A pKi 8.63 8.63 8.63 Guide to Pharmacology
A3 AA3R Human Adenosine A pKi 6.0 6.0 6.0 Guide to Pharmacology
A3 AA3R Mouse Adenosine A pKi 5.0 5.0 5.0 Guide to Pharmacology
A2B AA2BR Mouse Adenosine A pKi 8.07 8.07 8.07 Guide to Pharmacology
A1 AA1R Mouse Adenosine A pKi 5.02 5.02 5.02 Guide to Pharmacology
A2A AA2AR Mouse Adenosine A pKi 5.08 5.08 5.08 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database