GPCRdb

avacopan

Agent/drug
Bioactivity

avacopan

SMILES	Cc1ccc(NC(=O)[C@H]2CCCN(C(=O)c3c(C)cccc3F)[C@H]2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F
InChIKey	PUKBOVABABRILL-YZNIXAGQSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	581.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Structure pdb	6C1R

No bioactivity data available.

avacopan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 3

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Structure pdb	6C1R

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Antineutrophil cytoplasmic antibody-associated vasculitis, unspecified	4A44.AZ	L04A	0.376	4	Yes
C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Granulomatosis with polyangiitis	4A44.A1	L04A	0.464	4	Yes
C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Hidradenitis suppurativa	ED92.0	L04A	0.075	2	Yes
C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Microscopic polyangiitis	4A44.A0	L04A	0.463	4	Yes
C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Nephritic syndrome	GB40	L04A	0.113	2	Yes
C5AR1	C5a₁ receptor	Complement peptide receptors	Peptide receptors	Class A	Other specified hereditary haemolytic anaemia	3A10.Y	L04A	0.076	2	Yes

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