GPCRdb

(-)-baclofen

Agent/drug
Bioactivity

(-)-baclofen

SMILES	NC[C@H](CC(=O)O)c1ccc(Cl)cc1
InChIKey	KPYSYYIEGFHWSV-QMMMGPOBSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	4
Molecular weight (Da)	213.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank DrugBank Guide To Pharmacology PubChem PubChem GPCRdb
Structure pdb	7EB2 7C7Q

No bioactivity data available.

(-)-baclofen

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 8

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank DrugBank Guide To Pharmacology PubChem PubChem GPCRdb
Structure pdb	7EB2 7C7Q

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

GABR1	GABA_B1	GABA_B receptors	Amino acid receptors	Class C	Autism spectrum disorder, unspecified	6A02.Z		0.161	3	No
GABR1	GABA_B1	GABA_B receptors	Amino acid receptors	Class C	Cramp or spasm	MB47.3		0.382	3	No
GABR1	GABA_B1	GABA_B receptors	Amino acid receptors	Class C	Fragile X chromosome	LD55		0.362	3	No
GABR2	GABA_B2	GABA_B receptors	Amino acid receptors	Class C	Autism spectrum disorder, unspecified	6A02.Z		0.172	3	No
GABR2	GABA_B2	GABA_B receptors	Amino acid receptors	Class C	Cramp or spasm	MB47.3		0.572	3	No
GABR2	GABA_B2	GABA_B receptors	Amino acid receptors	Class C	Fragile X chromosome	LD55		0.363	3	No

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