ACTH-(1-24) [574]



ACTH-(1-24)


SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C
InChIKey ZOEFCCMDUURGSE-SQKVDDBVSA-N
Sequence SYSMEHFRWGKPVGKKRRPVKVYP
HELM PEPTIDE1{S.Y.S.M.E.H.F.R.W.G.K.P.V.G.K.K.R.R.P.V.K.V.Y.P}$$$$

Chemical Properties

Hydrogen bond acceptors 39
Hydrogen bond donors 39
Rotatable bonds 93
Log P -8.594
Molecular weight (Da) 2931.6
Stereochemistry info unspecified

Database connections

Model (AF2) MC4
Model (Boltz2) MC2
GPCRdb related ligands

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

ACTH-(1-24)


Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Distribution across phases (no. indications)

Phase I 0
Phase II 1
Phase III 1
Phase IV 1

Database connections

Model (AF2) MC4
Model (Boltz2) MC2

Sankey plot

Drug Information

Target Disease
Gene Protein Receptor family Ligand type Class Name Phase ICD11 ATC Association score