GSK-1004723


SMILES O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1
InChIKey YANGEESWIGIKOP-UUWRZZSWSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 14
Molecular weight (Da) 640.4

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pKi 7.5 7.5 7.5 ChEMBL
H1 HRH1 Human Histamine A pKd 9.1 9.1 9.1 ChEMBL
H1 HRH1 Human Histamine A pKi 7.8 7.95 8.0 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.4 7.4 7.4 ChEMBL
H3 HRH3 Human Histamine A pKi 9.6 9.6 9.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 5.0 5.0 5.0 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.0 5.0 5.0 ChEMBL