A-794278


SMILES CN(c1ccnc2c1c1ncn(c(=O)c1s2)C1CCCCCC1)C
InChIKey WOADNNTWYZOWNV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 342.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.27 8.27 8.27 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.0 8.0 8.0 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 9.0 9.0 9.0 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.83 6.83 6.83 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 9.0 9.0 9.0 ChEMBL